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噴昔洛韋,≥99%
??【編號】:125160

??【產品名稱】:噴昔洛韋,≥99%

??【規格】:50MG

??【用途】:

  噴昔洛韋,≥99%

  Product Name: Penciclovir
  別名:6H-Purin-6-one, 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-
  CAS號:39809-25-1
  分子式:C10H15N5O3
  分子量:253.26
  介紹: Penciclovir
  貯存: 儲存溫度-20°C
  可溶性:
  DMSO 34 mg/mL
  Water 1 mg/mL
  Ethanol <1 mg/mL
  生化和生理學機理:
  Description: IC50 Value: 2.3±0.8 mg/ml(EC50, inhibition EBV DNA synthesis); >100mg/ml(50% cell growth inhibitory concentration of both P3HR-1 and Raji cells) Penciclovir, a novel acyclic nucleoside analogue, has demonstrated efficacy against HSV types 1 and 2 and seems to have a pharmacological advantage due to a prolonged half-life of its active form in HSV-infected cells[1]. in vitro: Treatment with GCV or PCV induced rapid accumulation of cells in S-phase and apoptotic death, GCV (and to a lesser extent PCV) increased phosphatidyl serine translocation, induced positive TUNEL results with alterations in cell morphology, caused marked propidium iodide staining and induced DNA laddering. [2]. B-95-8 cells were treated with penciclovir or aciclovir at 1 and 10 ug/ml for 7 days, At 1 ug/ml, both compounds were inactive, but at 10 ug/ml, the virus yield relative to that of untreated virus controls was reduced by 94 and 86% by penciclovir and aciclovir, respectively[5]. in vivo: Penciclovir pharmacokinetics following oral administration of famciclovir were nonlinear within the dosage range studied, likely because of saturation of famciclovir metabolism[3]. Treatment with penciclovir (intravenous formulation) was associated with the development of resistant HSV in only one severely immunocompromised patient (day 7 isolate IC(50) = 2.01 microg/ml), although treatment was effective and resulted in the complete clearance of the lesion by day 8. No patients receiving topical penciclovir developed treatment-associated penciclovir-resistant HSV[4]. Clinical trial: A Comparative Study of the Efficacy of Penciclovir 10 mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers. Phage4
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